Paleolithic diet fraction in post hoc data analysis of a randomized cross-over study comparing Paleolithic diet with diabetes diet

BackgroundPaleolithic Diet Fraction (PDF), calculated as the fraction of intake from Paleolithic food groups divided by all groups, was developed a measure compliance hitherto lacking in interventional studies on diet. Mean PDFs our previously published study comparing diet with Mediterranean-like were around 80% and 40% for two diets, respectively, higher PDF associated healthier levels several glucometabolic outcome measures. We now present diabetes diet.Methods13 adult patients (3 women 10 men, mean age 64) type 2 followed 2005–07 during consecutive 3-month periods randomized order cross-over design study. daily using four-day weighed records. Linear mixed models used to assess associations between relative change measures this aggregated data combined diet.ResultsMean energy 77% 38% The corresponding percentages weight 81% 54%. A 10% 0.8% lower weight, 0.7% smaller waist circumference, 2.1% total cholesterol, 7.6% triglyceride, 2.0% HbA1C, 9.9% leptin and, data, also 1.6% area under curve (AUC) glucose an oral tolerance test (OGTT). Similar results found weight.ConclusionsA both previous indicate high reproducibility PDF. indicates their similarity how far removed diets are terms group content. that removal is unhealthy. post hoc analysis should be corroborated future studies.Trial registrationClinicalTrials.gov. NCT00435240. Registered 14 February 2007. Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT00435240?term=tommy+jönsson&cond=paleolithic&draw=2&rank=2.